Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug?

Adenosine receptors and its ligands

Adenosine and adenosine receptors in rheumatoid arthritis

Rheumatoid arthritis is one of the most important chronic, progressive and disabling inflammatory diseases characterized by joint destructive process associated with synovial proliferation and secretion of high levels of proinflammatory mediators including cytokines and growth factors. Early diagnosis and effective therapy are crucial in order to prevent unfavorable outcome with joint deteriora...

P138: Are Depression and Anxiety Affected by Adenosine A2A Receptors?

Adenosine acts as neuromodulator in the brain, which its involvement in a wide range of brain processes and diseases has been studied, such as epilepsy, sleep, anxiety, panic disorder, Alzheimer’s disease, Parkinson’s disease and schizophrenia. Adenosine receptors have been detected: A1R, A2AR (A2AR), A2BR, and A3R. A1R and A2R inhibit cAMP production, while A2AR and A2BR stimulate cAMP product...

The roles of adenosine and adenosine receptors in bone remodeling.

Adenosine regulates a wide variety of physiological processes including heart rate, vasodilation and inflammation through the activation of specific cell surface adenosine receptors. In addition to these well-established roles of adenosine, recent genetic and pharmacological research has implicated adenosine as an important regulator in bone remodeling. The secretion of adenosine and the presen...

Special Issue: Adenosine Receptors.

Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. [...].